Brief report novel mechanism for valproate-induced teratogenicity
نویسندگان
چکیده
منابع مشابه
Valproate teratogenicity and epilepsy syndrome.
Maternal valproate (VPA) use is associated with a significant risk for congenital malformations in the exposed fetus. Since VPA is commonly used in epilepsy syndromes with a presumed genetic cause (idiopathic epilepsies), it is possible that maternal genetic background contributes to this outcome. We reviewed responses to telephone questionnaires and medical records, when available, of enrollee...
متن کاملMechanism for Valproate Encephalopathy
Sin,—Hyperglycinsemia, hyperglycinuria,l propionicaciduria2 and Reye’s syndrome3 have been reported in epileptic patients taking the anticonvulsant drug valproic acid (VPA). While investigating possible mechanisms of VPA toxicity we found increased plasma glycine and propionic acid concentrations in symptom-free patients taking VPA (table i). With informed consent, loading tests with 500 ...
متن کاملValproate-induced hyperammonemic encephalopathy: a case report and brief review of the literature.
Almost 50 years after its discovery, valproic acid remains a mainstay in the treatment of epilepsy, both alone and in combination with other anticonvulsants. It is also associated with a hyperammonemic encephalopathy, when used in combination with other drugs. We present a case of valproate-induced hyperammonemic encephalopathy in a patient on multiple anticonvulsant and psychotropic medication...
متن کاملCommon Mechanism for Teratogenicity of Antiepileptic Drugs
Azarbayjani, F. 2001. Common mechanism for teratogenicity of antiepileptic drugs. Drug induced embryonic arrhythmia and hypoxia-reoxygenation damage. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculy of Pharmacy 253. 54 pp. Uppsala.
متن کاملA mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Valproate (VPA) is one of several effective anti-epileptic and mood-stabilizing drugs, many of which are also potent teratogens in humans and several other mammalian species. Variable teratogenicity among inbred strains of laboratory mice suggests that genetic factors influence susceptibility. While studying the genetic basis for VPA teratogenicity in mice, we discovered that parental factors i...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2014
ISSN: 1542-0752
DOI: 10.1002/bdra.23277